Project: SRP091915
Organism: Homo sapiens
Study Title: Genome-wide chromosome conformation during early human cortical development
Center Name: UNIVERSITY OF CALIFORNIA LOS ANGELES
Description: Chromosome conformation capture experiments demonstrate that chromatin is organized into hierarchical structures, which include compartments, topological associating domains (TADs), and loops. These structures are thought to play a role in gene regulation and biological function by defining functional genomic units and mediating the effects of cis-regulatory elements via both short- and long-range physical interactions. We constructed Hi-C libraries in mid gestation fetal cerebral cortex from three individuals during the peak of neurogenesis and migration (gestation week, GW17-18). We reasoned that it would be useful to analyze mitotically active neuronal precursors involved in neurogenesis separately from post-mitotic migrating and maturing neurons, so we dissected the cortical anlage into two major structures: the cortical and subcortical plate (CP), consisting primarily of post mitotic neurons and the germinal zone (GZ), containing primarily mitotically... (for more see dbGaP study page.)
Cell Type: notcancer-liver
Median Sequencing Depth: 0.000000
Publication: Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver
DOI: 10.1126/sciadv.aax2659