SRP356287

   Project:  SRP356287
   Organism:  Homo sapiens
   Study Title:  Archival single cell sequencing reveals persistent subclones over years to decades of DCIS progression
   Center Name:  MD Anderson Cancer Center
   Description:  We developed Arc-well, the first high-throughput method that can perform single cell DNA sequencing of thousands of cells from FFPE tissues. We validated our method by profiling 40,330 single cells from cell lines, a frozen tissue, and 27 FFPE samples from breast, lung, and prostate tumors stored for 3-31 years. Our data show that in DCIS with recurrent DCIS/IDC, the dormant subclones were often missed during the initial treatment, having implications for both the clinical diagnosis and treatment of the disease.
   Cell Type:  Breast/Lung/Postrate cancer
   Median Sequencing Depth:  0.000000
   Publication:  Archival single-cell genomics reveals persistent subclones during DCIS progression
   DOI:  10.1016/j.cell.2023.07.024